Preheat the oven to 375°F. Butter a 9x13 inch baking dish.

Cook the macaroni according to the package instructions, until al dente. Drain and set aside.

In a large saucepan, melt the butter over medium heat. Add the flour and whisk until smooth, cooking for 2-3 minutes.

Gradually whisk in the milk, stirring constantly, until the sauce is smooth and thickened. Add the Dijon mustard, garlic powder, paprika, salt, and black pepper to taste.

Add the cheddar, Gruyere, and Parmesan cheeses, stirring until the cheese is melted and the sauce is smooth.

Add the cooked macaroni to the cheese sauce and stir until well combined.

Transfer the macaroni and cheese to the prepared baking dish.

In a small bowl, combine the panko breadcrumbs and chopped parsley. Sprinkle the breadcrumb mixture evenly over the macaroni and cheese.

Bake for 25-30 minutes, or until the topping is golden brown and the macaroni and cheese is bubbly.

Let the macaroni and cheese cool for 10 minutes before serving.